| Primary Identifier | IPR045315 | Type | Family |
| Short Name | Mtm1-like |
| description | This entry represents a group of mitochondrial carrier proteins, including Mtm1 from budding yeasts and SLC25A39/40 from humans. Mtm1 is apyridoxal 5'-phosphate (PLP) transporter and is involved in mitochondrial iron homeostasis []. SLC25A39 and its paralogue SLC25A40 are mitochondrial transporters essential for glutathione import into mitochondria, which is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis []. Knockdown of SLC25A39 in a zebrafish model has been shown to disrupt heme biosynthesis and results in profound anemia []. |
