| First Author | Abe R | Year | 1989 |
| Journal | J Exp Med | Volume | 170 |
| Issue | 4 | Pages | 1059-73 |
| PubMed ID | 2477483 | Mgi Jnum | J:10059 |
| Mgi Id | MGI:58516 | Doi | 10.1084/jem.170.4.1059 |
| Citation | Abe R, et al. (1989) Analysis of Mlsc genetics. A novel instance of genetic redundancy. J Exp Med 170(4):1059-73 |
| abstractText | The identity of the self determinants involved in the selection of the T cell repertoire has been a matter of considerable interest. In addition to the apparent critical role of MHC gene products, accumulated experimental results indicate the importance of non-MHC gene products in T cell repertoire selection. In particular, murine Mlsa and Mlsc determinants have been shown to be highly stimulatory to allogeneic T cells and to be involved in the negative selection (elimination) of self-reactive T cells expressing selected TCR V beta segments. In this work, a unique phenomenon of genetic redundancy is described in the control of Mlsc expression: Mlsc appears to be controlled by at least two unlinked loci, and the product of either one of these loci is sufficient to evoke Mlsc-specific T cell response and to act as a ligand in the deletion of self Mlsc-reactive V beta 3+ T cells. Based on these findings, we propose a possible explanation for the fact that Mls-like genes or gene products have not been identified in other species such as man. |
