| Primary Identifier | MGI:108295 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 19303 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables BH4 domain binding activity; MAP-kinase scaffold activity; and neuropilin binding activity. Involved in positive regulation of angiogenesis and transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including focal adhesion assembly; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Located in focal adhesion and lamellipodium. Is expressed in several structures, including central nervous system; genitourinary system; immune system; inner ear; and lens. Orthologous to human PXN (paxillin). PHENOTYPE: Homozygous mutant mice die at E9.5 with defects in the amnion, allantois, and headfold structures, as well as impaired growth, and abnormal heart and somite development; mutant fibroblasts show aberrant fibronectin-regulated focal adhesion dynamics, and disorganized membrane cytoskeletal structures. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
