Primary Identifier | MGI:2145349 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 105278 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic organ development; and negative regulation of smoothened signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human CDK20 (cyclin dependent kinase 20). PHENOTYPE: Mice homozygous for a null allele display exencephaly, open neural tubes, cleft palate, absence of the floor plate, achondroplasia of the radius and ulna, and abnormal cilia. [provided by MGI curators] |