| First Author | Hondowicz BD | Year | 2000 |
| Journal | Eur J Immunol | Volume | 30 |
| Issue | 7 | Pages | 2007-14 |
| PubMed ID | 10940890 | Mgi Jnum | J:63510 |
| Mgi Id | MGI:1861083 | Doi | 10.1002/1521-4141(200007)30:7<2007::AID-IMMU2007>3.0.CO;2-W |
| Citation | Hondowicz BD, et al. (2000) Maintenance of IL-12-responsive CD4+ T cells during a Th2 response in Leishmania major-infected mice. Eur J Immunol 30(7):2007-14 |
| abstractText | BALB/c and anti-IL-12-treated C3H mice infected with Leishmania major develop a Th2 cell response. However, in contrast to BALB/c mice, C3H mice treated transiently with an anti-IL-12 monoclonal antibody switch from a Th2 to a Th1 response and resolve their lesions once treatment is terminated. We report here that the critical difference in the Th2 response between BALB/c and C3H mice is in their ability to respond to IL-12. Thus, C3H mice with a Th2 response maintain a CD4+ T cell population that expresses IL-12 receptor beta1 and beta2 mRNA and produces IFN-gamma after exposure to IL-12. These results indicate that Th2 cell populations from different genetic backgrounds differ in their stability, and that this difference can be related to differential regulation of the IL-12 receptor. |
