| First Author | Schreiber V | Year | 1998 |
| Journal | Gene | Volume | 207 |
| Issue | 2 | Pages | 171-5 |
| PubMed ID | 9511759 | Mgi Jnum | J:46102 |
| Mgi Id | MGI:1197133 | Doi | 10.1016/s0378-1119(97)00622-7 |
| Citation | Schreiber V, et al. (1998) Chromosomal assignment and expression pattern of the murine Lasp-1 gene. Gene 207(2):171-5 |
| abstractText | The human Lasp-1 (LIM and SH3 protein) gene was previously identified by differential screening of a breast cancer- derived metastatic lymph node cDNA library. It was located on the q12 - q21 region of human chromosome 17 and was shown to be amplified and overexpressed in 12 % of breast tumours. Lasp-1 defines a new LIM-protein subfamily, as it associates a C-terminal Src homology 3 (SH3) domain to a N- terminal LIM motif. In this study, the isolation and characterization of the cDNA encoding the mouse Lasp-1 protein are described, and it is shown to be highly conserved with its human counterpart. In addition to the LIM and SH3 domains, both human and mouse Lasp-1 contain an actin-binding domain. The mouse gene was mapped by in situ hybridization to the 11C - 11D region of chromosome 11. Northern blot analysis shows that this gene is expressed from 7.5 to 17.5 days post-coitum of mouse embryogenesis and in almost all adult tissues. (C) 1998 Elsevier Science B.V. |
