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Publication : The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1.

First Author  Taskén K Year  1996
Journal  Genomics Volume  36
Issue  3 Pages  535-8
PubMed ID  8884279 Mgi Jnum  J:45325
Mgi Id  MGI:1195023 Doi  10.1006/geno.1996.0501
Citation  Tasken K, et al. (1996) The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1. Genomics 36(3):535-8
abstractText  We have determined the chromosomal localization of the gene for the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) to human chromosome 19 using polymerase chain reaction (PCR) and Southern blot analysis of two different somatic cell hybrid mapping panels. In addition, PCR analysis of a chromosome 19 mapping panel revealed the presence of a human C alpha-specific amplification product only in cell lines containing the region 19p13.1 to 19q12. Finally, two-color fluorescence in situ hybridization to metaphase chromosomes using the human C alpha cDNA and human chromosome 19 inter-Alu-PCR product as probes localized the human C alpha gene to chromosome region 19p13.1.
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