| Primary Identifier | MGI:5432111 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Ryr2 |
| Transmission | Germline | Strain of Origin | 129S/SvEv |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 45 was replaced with one in which nucleotide substitutions (CCC to TCT) result in the amino acid substitution of serine for proline at 2328 (P2328S), mimicking a mutation found in some catecholaminergic polymorphic ventricular tachycardia (CPVT) patients. A floxed neo cassette inserted downstream of exon 45 was removed by cre mediated recombination. |
