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Publication : Sequence analysis and expression of a mouse homolog of human IkappaBL gene.

First Author  Handel-Fernandez ME Year  1999
Journal  Biochim Biophys Acta Volume  1444
Issue  2 Pages  306-10
PubMed ID  10023090 Mgi Jnum  J:53338
Mgi Id  MGI:1332313 Doi  10.1016/s0167-4781(98)00282-6
Citation  Handel-Fernandez ME, et al. (1999) Sequence analysis and expression of a mouse homolog of human IkappaBL gene. Biochim Biophys Acta 1444(2):306-10
abstractText  The family of transcriptional inhibitors, IkappaBLs, are critical to the regulation of cytokine and chemokine production. We have identified the complete cDNA sequence of the mouse IkappabL gene. The predicted 381-amino-acid sequence showed evidence of two ankyrin repeats characteristic of Ikappab family proteins and 92% identity to the IkappaBL human homolog. Although human IkappaBL has been reported to be ubiquitously expressed, here we show that mouse IkappaBL is transcribed in a more tissue-specific manner.
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