| First Author | Pohl TM | Year | 1990 |
| Journal | FEBS Lett | Volume | 262 |
| Issue | 2 | Pages | 219-24 |
| PubMed ID | 2335203 | Mgi Jnum | J:10465 |
| Mgi Id | MGI:58916 | Doi | 10.1016/0014-5793(90)80194-n |
| Citation | Pohl TM, et al. (1990) The organisation of the mouse chromogranin B (secretogranin I) gene. FEBS Lett 262(2):219-24 |
| abstractText | A cosmid clone containing the gene for mouse chromogranin B (secretogranin I), a secretory protein found in secretory granules of most endocrine cells and neurons, was isolated and sequenced. The chromogranin B protein was found to be encoded by 5 exons which correspond to the cleaved signal peptide, the short N-terminal sequence preceding the disulfide-bonded loop structure, the disulfide-bonded loop structure itself, the large, variable region comprising approximately 90% of the protein, and the conserved C-terminal sequence. The promoter region of the chromogranin B gene is very GC-rich and contains a CATAA motif, a cAMP-responsive element and an Sp1 binding site. |
