| First Author | Lien WH | Year | 2006 |
| Journal | Science | Volume | 311 |
| Issue | 5767 | Pages | 1609-12 |
| PubMed ID | 16543460 | Mgi Jnum | J:106707 |
| Mgi Id | MGI:3619284 | Doi | 10.1126/science.1121449 |
| Citation | Lien WH, et al. (2006) alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science 311(5767):1609-12 |
| abstractText | During development, cells monitor and adjust their rates of accumulation to produce organs of predetermined size. We show here that central nervous system-specific deletion of the essential adherens junction gene, alphaE-catenin, causes abnormal activation of the hedgehog pathway, resulting in shortening of the cell cycle, decreased apoptosis, and cortical hyperplasia. We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex. |
