| First Author | Chen J | Year | 2002 |
| Journal | Mech Ageing Dev | Volume | 123 |
| Issue | 2-3 | Pages | 145-53 |
| PubMed ID | 11718808 | Mgi Jnum | J:73732 |
| Mgi Id | MGI:2156332 | Doi | 10.1016/s0047-6374(01)00347-5 |
| Citation | Chen J, et al. (2002) A reduced peripheral blood CD4(+) lymphocyte proportion is a consistent ageing phenotype. Mech Ageing Dev 123(2-3):145-53 |
| abstractText | Peripheral blood leukocyte composition was measured in young, middle-aged and old C57BL/6J (B6) and BALB/cByJ (BALB) mice by flow cytometry to test the hypothesis that ageing is associated with declines in the proportions of peripheral blood T lymphocytes. In both B6 and BALB mice, increasing age is associated with a significant and continuous decline in the proportions of CD4(+) lymphocytes, a moderate decline in the proportion of CD8(+) lymphocytes, a significant increase in the proportion of Gr1(+) granulocytes and an almost unchanged proportion of B lymphocytes. As expected, the proportion of CD44(low) naive T lymphocytes decreased with age. Expression of Fas (CD95(+)) on CD4(+) and CD8(+) lymphocytes showed no consistent change with age. We also measured peripheral blood CD4(+) and CD8(+) lymphocyte proportions in young and old A/J, CBA/CaJ, DBA/2J, DW/J and (DWxC3H) F1 mice. The CD4(+) lymphocyte proportion decreased from young to old age in these strains by 56,65,72,78 and 68%, respectively. The CD8(+) lymphocyte proportion decreased moderately with age in all the inbred strains tested but not in the (DWxC3H) F1 hybrid. Thus, a reduced proportion of peripheral blood CD4(+) lymphocytes is a consistent ageing phenotype in a wide range of Mus musculus strains. |
