| First Author | Stanford SM | Year | 2012 |
| Journal | Immunology | Volume | 137 |
| Issue | 1 | Pages | 1-19 |
| PubMed ID | 22862552 | Mgi Jnum | J:189669 |
| Mgi Id | MGI:5446833 | Doi | 10.1111/j.1365-2567.2012.03591.x |
| Citation | Stanford SM, et al. (2012) Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology 137(1):1-19 |
| abstractText | More than half of the known protein tyrosine phosphatases (PTPs) in the human genome are expressed in T cells, and significant progress has been made in elucidating the biology of these enzymes in T-cell development and function. Here we provide a systematic review of the current understanding of the roles of PTPs in T-cell activation, providing insight into their mechanisms of action and regulation in T-cell receptor signalling, the phenotypes of their genetically modified mice, and their possible involvement in T-cell-mediated autoimmune disease. Our projection is that the interest in PTPs as mediators of T-cell homeostasis will continue to rise with further functional analysis of these proteins, and PTPs will be increasingly considered as targets of immunomodulatory therapies. |
