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Gene Segment : Igha immunoglobulin heavy constant alpha

Primary Identifier  MGI:96444 Organism  mouse, laboratory
Chromosome  12 Mgi Type  gene segment
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables antigen binding activity. Acts upstream of or within humoral immune response mediated by circulating immunoglobulin and mucosal immune response. Part of immunoglobulin complex, circulating. Is expressed in large intestine and small intestine. Orthologous to human IGHA1 (immunoglobulin heavy constant alpha 1) and IGHA2 (immunoglobulin heavy constant alpha 2 (A2m marker)).
PHENOTYPE: Homozygous null mice have no detectable levels of IgA, decreased levels of IgG3, and increased levels of most other classes of immunoglobulins. [provided by MGI curators]
  • synonyms:
  • immunoglobulin heavy constant alpha,
  • IgA,
  • Igh-2,
  • MGD-MRK-11241,
  • immunoglobulin heavy chain 2 (serum IgA),
  • Igha

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

5 Pathways

Trail: GeneSegment

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For