| Primary Identifier | IPR032672 | Type | Family |
| Short Name | TmcA/NAT10/Kre33 |
| description | This entry includes bacterial tRNA(Met) cytidine acetyltransferase TmcA, budding yeast Kre33, fission yeast and mammalian N-acetyltransferase 10 (NAT10). They consist of an RNA helicase domain and a GCN5-related N-acetyltransferase (GNAT) domain. TmcA catalyses the formation of N(4)-acetylcytidine (ac4C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and either ATP or GTP []. This modification is thought to ensure precise recognition of the AUG codon by strengthening C-G base-pair interaction and also prevent misrecognition of the near cognate AUA codon []. Kre33 and NAT10 are RNA cytidine acetyltransferases with specificity toward both 18S rRNA and tRNAs [, , ]. |
