| First Author | Yoshihara Y | Year | 1994 |
| Journal | Neuron | Volume | 12 |
| Issue | 3 | Pages | 541-53 |
| PubMed ID | 7794412 | Mgi Jnum | J:38192 |
| Mgi Id | MGI:85580 | Doi | 10.1016/0896-6273(94)90211-9 |
| Citation | Yoshihara Y, et al. (1994) An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression. Neuron 12(3):541-53 |
| abstractText | Telencephalin (TLN) is a 130 kd glycoprotein expressed exclusively in neurons of the telencephalon, the most rostral brain segment. In the neurons, TLN is localized to soma-dendritic membrane but not to axonal membrane. In this study, we have cloned cDNA encoding rabbit and mouse TLN. The cDNA-derived primary structure of TLN predicts an integral membrane protein with nine tandem immunoglobulin-like domains in an extra-cellular region, a transmembrane domain, and a short cytoplasmic tail. The distal eight immunoglobulin-like domains of TLN show highest homology with the immunoglobulin-like domains of intracellular adhesion molecules (ICAMs) 1, 2, and 3/R. The structural similarity of TLN with ICAMs provides a new and strong link between immunoglobulin superfamily molecules in the nervous and immune systems. TLN is an example of a dendrite-associated cell adhesion molecule involved in the brain's segmental organization, cell-cell interactions during dendritic development, and maintenance of functional neuronal networks. |
