| Primary Identifier | IPR030434 | Type | Family |
| Short Name | CLPTM1L |
| description | Cleft lip and palate transmembrane protein 1-like protein (CLPTM1L), also known as CRR9 (cisplatin resistance-related protein 9), is a scramblase that mediates the translocation glucosaminylphosphatidylinositol (alpha-D-GlcN-1-6-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI) []. This transmembrane protein is overexpressed in non-small cell lung cancer, where it protects tumour cells from genotoxic apoptosis []. It has been identified as an overexpressed protein in human ovarian tumour cell lines that are resistant to cisplatin []. CLPTM1L may protect cells from genotoxic stress induced apoptosis through regulation of Bcl-xL []. It interacts with phosphoinositide 3-kinase and is essential for Ras-induced AKT phosphorylation []. The CLPTM1L gene lies within a cancer susceptibility locus at chromosome 5p15.33 (TERT-CLPTM1L) defined by genome-wide association studies [].This entry also includes CLPTM1-like membrane protein cnrB from slime molds |
