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Protein Coding Gene : Slc18a3 solute carrier family 18 (vesicular monoamine), member 3
Primary Identifier  MGI:1101061 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  20508
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable acetylcholine:proton antiporter activity and monoamine:proton antiporter activity. Involved in neurotransmitter loading into synaptic vesicle; positive regulation of neuromuscular junction development; and positive regulation of synaptic transmission. Located in cytoplasm and terminal bouton. Is active in cholinergic synapse. Is expressed in several structures, including esophagus; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 21. Orthologous to human SLC18A3 (solute carrier family 18 member A3).
PHENOTYPE: Mice homozygous for a null allele exhibit decreased acetylcholine release, grip strength, coordination, exercise endurance, and social recognition memory. [provided by MGI curators]
  • synonyms:
  • Slc18a3,
  • solute carrier family 18 (vesicular monoamine), member 3,
  • VAChT,
  • VAT
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Trail: ProteinCodingGene

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