| First Author | Abeliovich A | Year | 1993 |
| Journal | Cell | Volume | 75 |
| Issue | 7 | Pages | 1253-62 |
| PubMed ID | 8269509 | Mgi Jnum | J:16392 |
| Mgi Id | MGI:64473 | Doi | 10.1016/0092-8674(93)90613-u |
| Citation | Abeliovich A, et al. (1993) Modified hippocampal long-term potentiation in PKC gamma-mutant mice. Cell 75(7):1253-62 |
| abstractText | Calcium-phospholipid-dependent protein kinase (PKC) has long been suggested to play an important role in modulating synaptic efficacy. We have created a strain of mice that lacks the gamma subtype of PKC to evaluate the significance of this brain-specific PKC isozyme in synaptic plasticity. Mutant mice are viable, develop normally, and have synaptic transmission that is indistinguishable from wild-type mice. Long-term potentiation (LTP), however, is greatly diminished in mutant animals, while two other forms of synaptic plasticity, long-term depression and paired-pulse facilitation, are normal. Surprisingly, when tetanus to evoke LTP was preceded by a low frequency stimulation, mutant animals displayed apparently normal LTP. We propose that PKC gamma is not part of the molecular machinery that produces LTP but is a key regulatory component. |
