| First Author | Yan Y | Year | 2013 |
| Journal | Immunity | Volume | 38 |
| Issue | 6 | Pages | 1154-63 |
| PubMed ID | 23809162 | Mgi Jnum | J:207575 |
| Mgi Id | MGI:5559132 | Doi | 10.1016/j.immuni.2013.05.015 |
| Citation | Yan Y, et al. (2013) Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 38(6):1154-63 |
| abstractText | Omega-3 fatty acids (omega-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with omega-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1beta secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein beta-arrestin-2 were shown to be involved in inflammasome inhibition induced by omega-3 FAs. Importantly, omega-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and metabolic disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which omega-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of omega-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases. |
