| First Author | Affolter M | Year | 2008 |
| Journal | Dev Cell | Volume | 15 |
| Issue | 1 | Pages | 11-22 |
| PubMed ID | 18606137 | Mgi Jnum | J:140887 |
| Mgi Id | MGI:3814782 | Doi | 10.1016/j.devcel.2008.06.006 |
| Citation | Affolter M, et al. (2008) Signal-induced repression: the exception or the rule in developmental signaling?. Dev Cell 15(1):11-22 |
| abstractText | Cell-cell communication plays a key role in organ formation and patterning in multicellular animals and is carried out by a few evolutionarily conserved signaling pathways. The modes of action of these pathways share a number of general properties, or habits, that allow them to strongly activate target genes in a ligand-dependent manner in the proper cellular contexts. Recent studies have revealed that some developmental signaling pathways can also strongly repress genes in a ligand-dependent manner. These new findings raise the interesting possibility that this repressive mode of action is shared by many or most developmental signaling pathways. |
