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Publication : Influence of interferon-alpha2b (IFN-alpha2b) on the prevention of locally advanced bladder carcinoma in mice.

First Author  Otto T Year  1999
Journal  Urol Res Volume  27
Issue  6 Pages  489-92
PubMed ID  10651139 Mgi Jnum  J:60013
Mgi Id  MGI:1352532 Doi  10.1007/s002400050140
Citation  Otto T, et al. (1999) Influence of interferon-alpha2b (IFN-alpha2b) on the prevention of locally advanced bladder carcinoma in mice. Urol Res 27(6):489-92
abstractText  In the model of chemically induced bladder carcinoma in mice following application of betahydroxylbutylnitrosamine (BBN) we could not detect a therapeutic influence of systemic treatment with intraperitoneal injection of interferon-alpha2b (10x3x10(5) IU IFN-alpha2b) on the rate of locally advanced bladder carcinoma (IFN-alpha2b 37% versus control 41%) nor on the development of tumor precursors (severe dysplasia 100% in both groups).
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