| Primary Identifier | MGI:2444773 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 228607 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables signaling adaptor activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within positive regulation of cytokine production and regulation of defense response. Located in mitochondrion and peroxisome. Is expressed in cerebral cortex ventricular layer. Orthologous to human MAVS (mitochondrial antiviral signaling protein). PHENOTYPE: Homozygous and heterozygous mice for mutations display defective innate immunity in response to viral infections. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
