| Primary Identifier | MGI:2145458 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 105387 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables androsterone dehydrogenase activity. Predicted to be involved in several processes, including cellular response to hormone stimulus; primary alcohol metabolic process; and regulation of lipid biosynthetic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in gut; liver; metanephros; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). PHENOTYPE: Mice homozygous for a conditional allele activated in the placenta exhibit sex-linked myelination alteration and autism-like behaviors in male mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
