| Primary Identifier | IPR027230 | Type | Family |
| Short Name | Ubc9 |
| description | SUMO proteins are ubiquitin like proteins that are covalently attached to and detached from other proteins in cells to modify their function. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability []. This entry represents the SUMO-conjugating enzyme Ubc9 (also known as UBE2I) and its homologue in plants, SCE1 [, , , , ]. |
