| First Author | Daniel WL | Year | 1976 |
| Journal | Biochem Genet | Volume | 14 |
| Issue | 11-12 | Pages | 1003-18 |
| PubMed ID | 1016219 | Mgi Jnum | J:5769 |
| Mgi Id | MGI:54246 | Doi | 10.1007/BF00485133 |
| Citation | Daniel WL (1976) Genetic control of heat sensitivity and activity level of murine arylsulfatase B. Biochem Genet 14(11-12):1003-18 |
| abstractText | BALB/c male mice possess twofold higher kidney p-nitrocatechol-SO4 arylsulfatase B than do A/HeJ male mice; however, their liver arylsulfatase activities are comparable. Twentyfold-purified kidney arylsulfatases B from these two strains have similar Michaelis constants, electrophoretic mobilities, pH optima, and inhibitor profiles; however, the BALB/c enzyme is more heat stable than the A/HeJ enzyme. BALB/c, C3H/HeJ, DBA/2J, and SWR/J mice share an autosomal allele, As-1a, which apparently determines the heat-stable arylsulfatase B, while A/HeJ and C57BL/6J mice possess the As-1b allele, which determines the heat-sensitive enzyme. A second autosomal locus, Asr-1, determines liver arylsulfatase B activity. C57BL/6J mice carry the Asr-1a allele, which results in high liver activities, while C3H/HeJ mice are homozygous for the low-activity allele, Asr-1b. Male mice generally have 30-40% higher kidney activities than females; however, female kidney arylsulfatase activities rise and actually surpass those of males during late pregnancy and lactation. |
