| First Author | Piercy J | Year | 2006 |
| Journal | Immunology | Volume | 118 |
| Issue | 2 | Pages | 250-6 |
| PubMed ID | 16771860 | Mgi Jnum | J:111956 |
| Mgi Id | MGI:3655235 | Doi | 10.1111/j.1365-2567.2006.02363.x |
| Citation | Piercy J, et al. (2006) CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells. Immunology 118(2):250-256 |
| abstractText | CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45-/- bone marrow dendritic cells (BMDC) are more activated than CD45+/+ cells and that tumour necrosis factor (TNF) and interleukin-6 (IL-6) production by BMDC and splenic dendritic cells (sDC), is increased following stimulation via Toll-like receptor (TLR)3 and TLR9. Nuclear factor-kappaB activation, an important downstream consequence of TLR3 and TLR9 signalling, is also increased in CD45-/- BMDC. BMDC of CD45-/- mice also produce more TNF and IL-6 following stimulation with the cytokines TNF and interferon-alpha. These results show that TLR signalling is increased in CD45-/- dendritic cells and imply that CD45 is a negative regulator of TLR and cytokine receptor signalling in dendritic cells. |
