| First Author | Dobrzanski P | Year | 1993 |
| Journal | Mol Cell Biol | Volume | 13 |
| Issue | 3 | Pages | 1572-82 |
| PubMed ID | 8441398 | Mgi Jnum | J:24211 |
| Mgi Id | MGI:71960 | Doi | 10.1128/mcb.13.3.1572 |
| Citation | Dobrzanski P, et al. (1993) Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif. Mol Cell Biol 13(3):1572-82 |
| abstractText | RelB, a member of the Rel family of transcription factors, can stimulate promoter activity in the presence of p50-NF-kappa B or p50B/p49-NF-kappa B in mammalian cells. Transcriptional activation analysis reveals that the N and C termini of RelB are required for full transactivation in the presence of p50-NF-kappa B. RelB/p50-NF-kappa B hybrid molecules containing the Rel homology domain of p50-NF-kappa B and the N and C termini of RelB have high transcriptional activity compared with wild-type p50-NF-kappa B. The N and C termini of RelB cooperate in transactivation in cis or trans configuration. Alterations in the structure of the leucine zipper-like motif present in the N terminus of RelB significantly decrease the transcriptional capacity of RelB and of different RelB/p50-NF-kappa B hybrid molecules. |
