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Protein Coding Gene : Usp8 ubiquitin specific peptidase 8
Primary Identifier  MGI:1934029 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  84092
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables cysteine-type deubiquitinase activity. Involved in endosome organization. Acts upstream of or within Ras protein signal transduction. Located in cytoplasmic vesicle membrane; cytosol; and midbody. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8).
PHENOTYPE: Embryos homozygous for a knock-out allele appear severely growth retarded and disorganized at E9.5 and die in utero due to ventral-folding defects. [provided by MGI curators]
  • synonyms:
  • MGI:2139401,
  • AW557536,
  • expressed sequence AI574262,
  • mKIAA0055,
  • expressed sequence AW557536,
  • Usp8,
  • AI574262,
  • Ubpy,
  • MGI:2139005,
  • ubiquitin specific peptidase 8
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Features --> Cross References

Genome

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0 Canonical

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2 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

14 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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