| Primary Identifier | MGI:88258 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 12326 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable calcium-dependent protein serine/threonine kinase activity; calmodulin binding activity; and calmodulin-dependent protein kinase activity. Involved in postsynapse to nucleus signaling pathway and postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including neuron-neuron synaptic transmission; positive regulation of DNA-templated transcription; and positive regulation of protein export from nucleus. Located in cytoplasm and nucleus. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV). PHENOTYPE: Homozygotes for different targeted mutations show variable phenotypes, including reduced viability, male and/or female sterility, and mild to severe neurological and spatial memory disorders. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
