| First Author | Morley JE | Year | 1995 |
| Journal | Life Sci | Volume | 57 |
| Issue | 14 | Pages | 1327-31 |
| PubMed ID | 7564879 | Mgi Jnum | J:29029 |
| Mgi Id | MGI:76554 | Doi | 10.1016/0024-3205(95)02089-2 |
| Citation | Morley JE, et al. (1995) Measurement of nitric oxide synthase and its mRNA in genetically obese (ob/ob) mice. Life Sci 57(14):1327-31 |
| abstractText | Recent studies have suggested a role for nitric oxide (NO) in the regulation of food intake. The obese (ob/ob) mouse is a genetic model of obesity. Previously, it has been demonstrated that ob/ob mice show a marked weight reduction when treated with a nitric oxide synthase inhibitor. In the studies reported here, we demonstrate increased levels of nitric oxide synthase (NOS) and its mRNA in the hypothalamus of genetically obese (ob/ob) mice compared to their lean littermate controls (ob/c). NOS levels were 0.016 +/- 0.001 nmol/mg/min in ob/ob compared to 0.009 +/- 0.001 in ob/c (p < 0.01) and NOS mRNA was 32.0 +/- 5.0 pg NOS mRNA/mg total RNA in ob/ob compared to 12.4 +/- 4.0 in ob/c (p < 0.05). These studies further support the possibility of a role for nitric oxide in the regulation of food intake. |
