| First Author | Woo HN | Year | 2008 |
| Journal | Neuroreport | Volume | 19 |
| Issue | 12 | Pages | 1193-7 |
| PubMed ID | 18628663 | Mgi Jnum | J:137859 |
| Mgi Id | MGI:3803066 | Doi | 10.1097/WNR.0b013e3283089209 |
| Citation | Woo HN, et al. (2008) Characterization of subcellular localization and Ca2+ modulation of calsenilin/DREAM/KChIP3. Neuroreport 19(12):1193-7 |
| abstractText | Earlier reports found that calsenilin is a transcriptional repressor or a subunit of plasma membrane channel, and indicated that calsenilin was present in the nucleus or plasma membrane. Immunohistochemical and subcellular fractionation analysis, however, revealed that calsenilin/DREAM/KChIP3 was distributed throughout the cytoplasm of SK-N-BE2(C), Jurkat, and HeLa cells. In addition, the expression of calsenilin suppressed the ATP-induced increase in intracellular Ca2+ concentrations. By increase in intracellular calcium concentration, calsenilin was translocated into the nucleus. |
