| First Author | Johansson JK | Year | 2010 |
| Journal | Genesis | Volume | 48 |
| Issue | 6 | Pages | 374-81 |
| PubMed ID | 20533404 | Mgi Jnum | J:163480 |
| Mgi Id | MGI:4822092 | Doi | 10.1002/dvg.20628 |
| Citation | Johansson JK, et al. (2010) N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover. Genesis 48(6):374-81 |
| abstractText | The cadherin family of cell adhesion molecules mediates adhesive interactions that are required for the formation and maintenance of tissues. Previously, we demonstrated that N-cadherin, which is required for numerous morphogenetic processes, is expressed in the pancreatic epithelium at E9.5, but later becomes restricted to endocrine aggregates in mice. To study the role of N-cadherin during pancreas formation and function we generated a tissue-specific knockout of N-cadherin in the early pancreatic epithelium by inter-crossing N-cadherin-floxed mice with Pdx1Cre mice. Analysis of pancreas-specific ablation of N-cadherin demonstrates that N-cadherin is dispensable for pancreatic development, but required for beta-cell granule turnover. The number of insulin secretory granules is significantly reduced in N-cadherin-deficient beta-cells, and as a consequence insulin secretion is decreased. |
