| First Author | Cantor DJ | Year | 2019 |
| Journal | Cell Rep | Volume | 26 |
| Issue | 1 | Pages | 108-118.e4 |
| PubMed ID | 30605667 | Mgi Jnum | J:284079 |
| Mgi Id | MGI:6380866 | Doi | 10.1016/j.celrep.2018.12.030 |
| Citation | Cantor DJ, et al. (2019) Impaired Expression of Rearranged Immunoglobulin Genes and Premature p53 Activation Block B Cell Development in BMI1 Null Mice. Cell Rep 26(1):108-118.e4 |
| abstractText | B cell development is a highly regulated process that requires stepwise rearrangement of immunoglobulin genes to generate a functional B cell receptor (BCR). The polycomb group protein BMI1 is required for B cell development, but its function in developing B cells remains poorly defined. We demonstrate that BMI1 functions in a cell-autonomous manner at two stages during early B cell development. First, loss of BMI1 results in a differentiation block at the pro-B cell to pre-B cell transition due to the inability of BMI1-deficient cells to transcribe newly rearranged Igh genes. Accordingly, introduction of a pre-rearranged Igh allele partially restored B cell development in Bmi1(-/-) mice. In addition, BMI1 is required to prevent premature p53 signaling, and as a consequence, Bmi1(-/-) large pre-B cells fail to properly proliferate. Altogether, our results clarify the role of BMI1 in early B cell development and uncover an unexpected function of BMI1 during VDJ recombination. |
