| First Author | Lee MM | Year | 2005 |
| Journal | Infect Immun | Volume | 73 |
| Issue | 1 | Pages | 661-5 |
| PubMed ID | 15618213 | Mgi Jnum | J:94836 |
| Mgi Id | MGI:3521594 | Doi | 10.1128/IAI.73.1.661-665.2005 |
| Citation | Lee MM, et al. (2005) Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infect Immun 73(1):661-5 |
| abstractText | Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance. |
