| First Author | Reynolds AB | Year | 1996 |
| Journal | Genomics | Volume | 31 |
| Issue | 1 | Pages | 127-9 |
| PubMed ID | 8808291 | Mgi Jnum | J:30893 |
| Mgi Id | MGI:78507 | Doi | 10.1006/geno.1996.0020 |
| Citation | Reynolds AB, et al. (1996) The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). Genomics 31(1):127-9 |
| abstractText | The p120(cas) gene encodes a protein tyrosine kinase substrate that associates with the cell-cell adhesion protein complex containing E-cadherin and its cytoplasmic cofactors alpha-catenin, beta-catenin, and plakoglobin. Like other components of the cadherin/catenin complex, defects in p120(cas) may contribute to cell malignancy. We have determined the chromosomal location of the p120(cas) gene in human and mouse using fluorescence in situ hybridization and interspecific backcross analysis, respectively. The human p120(cas) gene (CTNND) is localized immediately adjacent to the centromere on the long arm of chromosome 11 in band 11q11. The murine p120(cas) gene (Catns) was assigned to the middle of chromosome 2. Neither locus is currently known to be associated with disease or malignancy. (C) 1996 Academic Press, Inc |
