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Allele : Runx1<tm5Toku> runt related transcription factor 1; targeted mutation 5, Tsukasa Okuda
Primary Identifier  MGI:6378825 Allele Type  Targeted
Attribute String  Not Specified Gene  Runx1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
description  E14-strain ES cells
molecularNote  Using site-directed mutagenesis, arginine codons 206 and 210 in exon 4 were changed to lysine codons (p.R206K, p.R210K). A puromycin resistance gene cassette was inserted downstream of the targeted codons in exon 4. The two targeted arginines are normally methylated as part of the regulation of the peptide's activity; lysines cannot be methylated.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Runx1<KTAMK>,
  • Runx1<KTAMK>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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