| Primary Identifier | MGI:103577 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15110 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and protein homodimerization activity. Acts upstream of or within several processes, including circulatory system development; regulation of transcription by RNA polymerase II; and trophoblast giant cell differentiation. Located in nucleolus and nucleoplasm. Is expressed in several structures, including alimentary system; early conceptus; heart and pericardium; nervous system; and urinary system. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1). PHENOTYPE: Homozygotes for targeted null mutations die at embryonic day 8.5-9.5 with yolk sac abnormalities associated with a deficiency of extraembryonic mesoderm and defective trophoblast differentiation. Tetraploid chimeric rescue slightly extends development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
