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Protein Coding Gene : Spag9 sperm associated antigen 9
Primary Identifier  MGI:1918084 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  70834
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables several functions, including JUN kinase binding activity; MAP-kinase scaffold activity; and kinesin binding activity. Acts upstream of or within positive regulation of MAPK cascade; positive regulation of neuron differentiation; and striated muscle cell differentiation. Located in cytoplasm. Is expressed in central nervous system; dorsal root ganglion; retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and liver cirrhosis. Orthologous to human SPAG9 (sperm associated antigen 9).
PHENOTYPE: Male mice homozygous for a null mutation display reduced fertility with oligoasthenozoospermia. [provided by MGI curators]
  • synonyms:
  • Spag9,
  • 4831406C20Rik,
  • JIP4,
  • MGI:1924388,
  • 3110018C07Rik,
  • syd1,
  • 4733401I23Rik,
  • MGI:2144568,
  • Mapk8ip4,
  • sperm associated antigen 9,
  • expressed sequence AW552012,
  • JLP,
  • MGI:1920413,
  • RIKEN cDNA 4831406C20 gene,
  • RIKEN cDNA 3110018C07 gene,
  • RIKEN cDNA 4733401I23 gene,
  • AW552012
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

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3 Involved In Mutations

Trail: ProteinCodingGene

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

2 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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