| First Author | Campbell P | Year | 2012 |
| Journal | Genetics | Volume | 191 |
| Issue | 4 | Pages | 1271-81 |
| PubMed ID | 22595240 | Mgi Jnum | J:185549 |
| Mgi Id | MGI:5429135 | Doi | 10.1534/genetics.112.141804 |
| Citation | Campbell P, et al. (2012) The contribution of the Y chromosome to hybrid male sterility in house mice. Genetics 191(4):1271-81 |
| abstractText | Hybrid sterility in the heterogametic sex is a common feature of speciation in animals. In house mice, the contribution of the Mus musculus musculus X chromosome to hybrid male sterility is large. It is not known, however, whether F1 male sterility is caused by X-Y or X-autosome incompatibilities or a combination of both. We investigated the contribution of the M. musculus domesticus Y chromosome to hybrid male sterility in a cross between wild-derived strains in which males with a M. m. musculus X chromosome and M. m. domesticus Y chromosome are partially sterile, while males from the reciprocal cross are reproductively normal. We used eight X introgression lines to combine different X chromosome genotypes with different Y chromosomes on an F1 autosomal background, and we measured a suite of male reproductive traits. Reproductive deficits were observed in most F1 males, regardless of Y chromosome genotype. Nonetheless, we found evidence for a negative interaction between the M. m. domesticus Y and an interval on the M. m. musculus X that resulted in abnormal sperm morphology. Therefore, although F1 male sterility appears to be caused mainly by X-autosome incompatibilities, X-Y incompatibilities contribute to some aspects of sterility. |
