| First Author | Kelley KA | Year | 1999 |
| Journal | Am J Pathol | Volume | 155 |
| Issue | 3 | Pages | 995-1004 |
| PubMed ID | 10487857 | Mgi Jnum | J:100973 |
| Mgi Id | MGI:3590115 | Doi | 10.1016/S0002-9440(10)65199-1 |
| Citation | Kelley KA, et al. (1999) Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am J Pathol 155(3):995-1004 |
| abstractText | In this study we describe the generation of a transgenic mouse model with neuronal overexpression of the human cyclooxygenase-2, h(COX)-2, to explore its role in excitotoxicity. We report that overexpression of neuronal hCOX-2 potentiates the intensity and lethality of kainic acid excitotoxicity in coincidence with potentiation of expression of the immediate early genes c-fos and zif-268. In vitro studies extended the in vivo findings and revealed that glutamate excitotoxicity is potentiated in primary cortico-hippocampal neurons derived from hCOX-2 transgenic mice, possibly through potentiation of mitochondrial impairment. This study is the first to demonstrate a cause-effect relationship between neuronal COX-2 expression and excitotoxicity. This model system will allow the systematic examination of the role of COX-2 in mechanisms of neurodegeneration that involve excitatory amino acid pathways. |
