Primary Identifier | IPR038203 | Type | Homologous_superfamily |
Short Name | Diapausin_sf |
description | This superfamily consists of diapausin-related antimicrobial peptides. Diapause during periods of environmental adversity is an essential part of the life cycle of many organisms, with the molecular basis being different among animals. Diapause-specific peptides (DSP) provide anti-fungal activity and act as N-type voltage-gated calcium channel blocker []. The overall structure of DSP is compact due to the three disulfide bridges that indicate a high similarity with insect- and plant-derived antifungal peptides. The DSP structure includes two α-helices and a triple-stranded β-sheet. The three disulfide bridges (Cys-7/Cys-21, Cys-11/Cys-33, and Cys-22/Cys-40) help the link between helices and the β-sheets []. |