| First Author | Brehm A | Year | 1998 |
| Journal | APMIS | Volume | 106 |
| Issue | 1 | Pages | 114-24; discussion 124-6 |
| PubMed ID | 9524569 | Mgi Jnum | J:46200 |
| Mgi Id | MGI:1197350 | Doi | 10.1111/j.1699-0463.1998.tb01326.x |
| Citation | Brehm A, et al. (1998) Oct-4: more than just a POUerful marker of the mammalian germline?. APMIS 106(1):114-24; discussion 124-6 |
| abstractText | Mammals lack visible cytoplasmic components in the oocyte that could account for germline determinants as identified in various non-mammalian species. Actually, mammals might not define the germline autonomously by localized germline determinants but conditionally depending on the position of cells within the embryo. The Oct-4 gene encodes a transcription factor that is specifically expressed in the toti- and pluripotential stem cells of the mouse embryo and so far has only been found in mammalian species. Oct-4-expressing embryonal cell retain the capacity to differentiate along multiple lineages and they have been suggested to be part of a totipotent germline cycle that links one generation to the next. |
