| Primary Identifier | MGI:2445476 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(GFAP-SRC)1Aag |
| Strain of Origin | (C57BL/6J x C3H)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Three transgenic lines were established. Lines src1 and src2 carry 5 and 32 copies, respectively, of the full-length SRC sequence whereas line src3 carries 8 copies of a 3' truncated SRC sequence. |
| molecularNote | The transgene was constructed by insertion of a viral SRC cDNA sequence from the Schmidt-Ruppin strain into exon 1 of GFAP. The GFAP promoter drives expression of the transgene in astrocytes of the brain. RT-PCR analysis of brain RNA from transgenic animals confirmed expression of the transgene. Transgene expression was also detected in lung, thymus, spleen, and gonads. |
