| First Author | Sapoznikov A | Year | 2008 |
| Journal | Nat Immunol | Volume | 9 |
| Issue | 4 | Pages | 388-95 |
| PubMed ID | 18311142 | Mgi Jnum | J:133263 |
| Mgi Id | MGI:3778156 | Doi | 10.1038/ni1571 |
| Citation | Sapoznikov A, et al. (2008) Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol 9(4):388-95 |
| abstractText | Beyond its established function in hematopoiesis, the bone marrow hosts mature lymphocytes and acts as a secondary lymphoid organ in the initiation of T cell and B cell responses. Here we report the characterization of bone marrow-resident dendritic cells (bmDCs). Multiphoton imaging showed that bmDCs were organized into perivascular clusters that enveloped blood vessels and were seeded with mature B lymphocytes and T lymphocytes. Conditional ablation of bmDCs in these bone marrow immune niches led to the specific loss of mature B cells, a phenotype that could be reversed by overexpression of the antiapoptotic factor Bcl-2 in B cells. The presence of bmDCs promoted the survival of recirculating B cells in the bone marrow through the production of macrophage migration-inhibitory factor. Thus, bmDCs are critical for the maintenance of recirculating B cells in the bone marrow. |
