| Primary Identifier | MGI:1277979 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 16415 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including ICAM-3 receptor activity; amyloid-beta binding activity; and integrin binding activity. Predicted to contribute to cell adhesion molecule binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of neutrophil degranulation. Predicted to act upstream of or within inflammatory response. Located in secretory granule. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2). PHENOTYPE: Mice homozygous for a null allele display normal leukocyte development and normal neutrophil recruitment to inflamed tissues. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
