| First Author | Nuñez-Cruz S | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 10 | Pages | 999-1008 |
| PubMed ID | 12970761 | Mgi Jnum | J:94074 |
| Mgi Id | MGI:3510774 | Doi | 10.1038/ni977 |
| Citation | Nunez-Cruz S, et al. (2003) LAT regulates gammadelta T cell homeostasis and differentiation. Nat Immunol 4(10):999-1008 |
| abstractText | LAT (linker for activation of T cells) is essential for T cell receptor signaling. Mice homozygous for a mutation of the three C-terminal LAT tyrosine residues showed a block in alphabeta T cell development and a partially impaired gammadelta T cell development. Without intentional immunization, they accumulated gammadelta T cells in the spleen and lymph nodes that chronically produced T helper type 2 cytokines in large amounts, and caused the maturation of plasma cells secreting immunoglobulin E (IgE) and IgG1. These effects are very similar to that triggered in the alphabeta lineage by a mutation involving a distinct LAT tyrosine. Thus, LAT is an essential regulator of T cell homeostasis and terminal differentiation. |
