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Allele : Ythdc2<em3Rspi> YTH domain containing 2; endonuclease-mediated mutation 3, Ramesh S Pillai
Primary Identifier  MGI:7466370 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Ythdc2
Inheritance Mode  Dominant Strain of Origin  (C57BL/6 x DBA/2)F1
Is Recombinase  false Is Wild Type  false
molecularNote  Glutamic acid codon 332 (GAA) in exon 7 was changed to glutamine (CAA) (p.E332Q) using crRNA, tracrRNA and an ssODN template with CRISPR/Cas9 technology. This mutation, in the N-terminal RecA module of the RNA helicase domain, inactivates the protein's ATPase and RNA helicase activities.
  • mutations:
  • Single point mutation
  • synonyms:
  • Ythdc2<cat-dead>,
  • Ythdc2<cat-dead>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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