| Primary Identifier | MGI:1277171 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 13193 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable microtubule binding activity and protein kinase binding activity. Involved in regulation of postsynapse assembly. Acts upstream of or within hippocampus development and neurogenesis. Located in cytoplasm and neuron projection. Is active in glutamatergic synapse. Is expressed in several structures, including limb mesenchyme; limb segment; nervous system; retina; and urinary system. Used to study lissencephaly. Human ortholog(s) of this gene implicated in X-linked lissencephaly 1 and subcortical band heterotopia. Orthologous to human DCX (doublecortin). PHENOTYPE: Males hemizygous for a null allele are fertile but show branching and nucleokinesis defects in migrating interneurons. Males hemizygous for a reporter allele show severe postnatal lethality and variable fertility; both female and male mutants display hippocampal dyslamination and behavioral defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
