| First Author | Burgess HA | Year | 1999 |
| Journal | J Neurosci Res | Volume | 58 |
| Issue | 4 | Pages | 567-75 |
| PubMed ID | 10533048 | Mgi Jnum | J:65156 |
| Mgi Id | MGI:1913120 | Citation | Burgess HA, et al. (1999) KIAA0369, doublecortin-like kinase, is expressed during brain development. J Neurosci Res 58(4):567-75 |
| abstractText | During embryonic development, the cerebral cortex attains its characteristic adult laminated structure. The finding that X-linked lissencephaly patients harbor mutations in the doublecortin gene implicated this gene product in the process of corticogenesis. An autosomal human gene, KIAA0369, with a high level of similarity to doublecortin, has been cloned from human adult brain. This gene product contains a kinase domain in addition to a doublecortin-like domain. In order to evaluate whether this doublecortin-like kinase also plays a role during brain development, we cloned and studied the expression pattern of the mouse homolog. Three cDNA products of this gene were cloned: one, doublecortin-like kinase, the second containing only the doublecortin-like region, and the third containing only the kinase domain, a homolog of the previously cloned rat CPG16 gene. We studied doublecortin-like kinase expression in mouse using Northern blot analysis, in situ hybridization, and Western blot analysis, and conclude that doublecortin-like kinase is expressed in multiple regions of embryonic brain including the developing cerebral cortex. Copyright 1999 Wiley-Liss, Inc. |
